propecia dosage forms ppt slides

PPT, gastroretentive, dosage, forms, powerPoint presentation

In addition to these unique pharmacokinetic properties, the pharmacodynamics of metformin is rather complex and does not follow a direct relationship between plasma drug concentration and magnitude of effect. However

, the magnitude of this pathway remains modest even in the case where the prolonged gastric retention of the bisphosphonate in rats is produced by experimental/surgical means. A free PowerPoint PPT presentation (displayed as a Flash slide show) on m - id: 478ed4-ZTZhM. To further increase the GRT of drugs, a gastroretentive dosage form (grdf) can be developed. I- Mouthwashes: These are similar to gargles but are used for oral hygiene and to treat infections of the mouth. Gastroretentive Dosage Forms - PowerPoint PPT Presentation. Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Reduced time intervals for drug administration. To view this presentation, you'll need to enable Flash. They are designed for administration to children.g. In some types, the valve is actuated by finger pressure, in other types the valve is actuated by the patient breathing in through the mouthpiece. However, immediate floating can only be achieved if the density of the device is low at the very beginning. A free PowerPoint PPT presentation (displayed as a Flash slide show) on m - id: 4e378f-NmVmN. Multilayer polymeric grdfs with size5 cm2.1 cm that were characterized by high rigidity retained alcohol in the human stomach for more than. The anatomical location of the CR-grdfs in the gastrointestinal tract was accomplished radiographically by incorporating the radiopaque threads in the dosage form.

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24 Minimized adverse activity at the colon Retention of the drug in the grdf at the stomach minimizes the amount of drug that reaches the colon. 37 Formulation Technologies The main approaches to prolonging the gastric residence time of pharmaceutical dosage forms include bioadhesive delivery systems, which adhere to mucosal surfaces devices that rapidly increase in size once they are in the stomach to retard the passage through the pylorus density-controlled. For a certain drug, interplay of its pharmacokinetic and pharmacodynamic parameters will determine the effectiveness and benefits of the CR-grdf compared to the other dosage forms. 4- extending its shelf life. B- water-in-oil (W/O) creams: which are composed of small droplets of water dispersed in a continuous oily phase. 72 Evaluation of novel CR-grdf formulation of levodopa in dogs As can be seen, while CR-grdf A produced too low a concentration and CR-grdf B had a short absorption phase, CR-grdf C produced elevated levodopa concentrations (gt500 ng ml) for more than 9 h after. Injection fibrosis is a complication that may occur if the injections are delivered with great frequency or with improper technique. Devices with an initially high density (which decreases with time) first settle down in the stomach and, inflammation thus, undergo the risk of premature emptying. Eye drops sometimes do not have medications in them and are only lubricating and tear-replacing solutions. 58 Floating drug delivery systems Drug delivery systems that float immediately upon contact with gastric fluids present promising approaches for increasing the bioavailability of drugs with absorption windows in the upper jack small intestine. Pills are now rarely used. B- Furnish an occlusive and macerating action. 13-Liquid preparations: a- Oral solution: Oral solutions are clear Liquid preparations for oral use containing one or more active ingredients dissolved in a suitable vehicle.

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The unfolding of the grdfs was studied applying gastroscopic equipment. The sponges were manufactured by freeze-drying a riboflavin-containing collagen solution. On the other hand, the bioavailability of riboflavin and levodopa CR-grdf is significantly enhanced in comparison to administration of non-grdf CR polymeric formulations. A barium enema is used as a contrast substance in the radiological imaging of the bowel. 30 Assessment of pkpd rationale for CR-grdf formulations in a rat model metformin as a model drug The gastric retention of the tablets was assessed radiographically in a separate study applying radiopaque markers added to the tablet formulation. 33 Assessment of pkpd rationale for CR-grdf formulations in a rat model metformin as a model drug Plasma metformin concentrations following administration of metformin (450 mg kg-1) as PO bolus, duodenal infusion, and gastroretentive CR tablets (CR I or CR II) to the streptozotocin-diab etic rats. The vehicle may contain a high proportion of ethanol or sucrose together with antimicrobial preservatives which confers the stability of the preparation. 3, gastroretentive Dosage Forms. The precompressed collagen was transported into a tablet machine for tablet compression. It is advantageous when a rapid onset of action is needed. The device has to be fitted inside or removed from the uterus by a doctor. 4- Chewable tablet: They are tablets that chewed prior to swallowing. It is commonly used in treating asthma, and other respiratory diseases.

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Compound Wart Remover consists of acetic acid and salicylic acid in sophia an acetone collodion base used in Treatment of warts by keratolysis. However, in the case of NAW drugs this pharmaceutical approach cannot be utilized since it requires sufficient colonic absorption percentuale of the drug (which is, by definition, not the case for NAW agents). 9 Gastroretentive Dosage meteorite Forms The main approaches that have been examined for gastroretentive drug delivery include low density of the grdf that causes buoyancy above gastric fluid high prezzo density which retains the dosage form (DF) in the body dott of the stomach that is anatomically lower. In general, appropriate candidates for CR-grdf are molecules that have poor colonic absorption but pagamento are characterized by better absorption properties at the upper parts of the GI tract.